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In the U.S., CVD is the leading cause of death, constitutes 17% of healthcare costs, and is estimated to increase in prevalence by ~10% and direct costs by almost three-fold over the next 20 years under current CVD prevention and treatment regimes [2]

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Co-immunization with CD86, and not CD80, was found to significantly enhance specific T-cell mediated responses, highlighting CD86s more potent effect as a molecular adjuvant (141, 142)

[DOI] [PubMed] [Google Scholar] 33.Abdelrazik H, Sharma R, Mahfouz R, Agarwal A

Both approaches work, and the most important factor is consistency rather than precise timing

BMC Med