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In addition, epithelial cells themselves contain abundant self-antigens and damage-associated molecular patterns

Critical for cartilage maintenance and repair

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Fifth, rapid gingival crevicular fluid turnover shortens local drug retention, while the periodontitis microenvironment degrades protein/peptide drugs and small-molecule inhibitors, reducing stability and bioavailability (117, 118)

The negative effects of ferroptosis in endothelial cells during AS are well established

Of the total 445 oral cancer patients, 192 were only RAN chewers and 253 were from both RAN and tobacco chewing category