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Histological investigation with H&E staining indicated that the sham group had normal testicular architecture, including intact seminiferous tubules and full spermatogenesis, which was consistent with previously described baseline testicular histomorphology in healthy adult rats 43

Based on the establishment and development of the theory of the pathological roles of free radicals, the role of GPxs has gradually attracted researchers attention, and the involvement of GPxs in the occurrence and development of malignant tumors has been shown

Probes are listed in Supplementary Data 2

However, this anticancer drug needs to be subjected to optimization, in addition to further assessment through multiple lab-based approaches to confirm its neuroprotection and toxicity by using MS models

doi: Poon HF, Farr SA, Thongboonkerd V, Lynn BC, Banks WA, Morley JE, Klein JB, Butterfield DA (2005) Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders

Aug 6 2021;100(31):e26706