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The four signs of a severe allergic reaction, also known as anaphylaxis, are difficulty breathing due to swelling of the airways, rapid pulse, a drop in blood pressure causing dizziness or fainting, and skin symptoms such as hives, itching or flushed or pale skin

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The nicotine acetylcholine receptors located in the neocortex, amygdala, hippocampus, and thalamus cause neuronal excitability by later activating the NMDA receptors and nitric oxide production

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