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It binds to the glucagon receptor (GCGR) in hepatocytes, thereby enhancing glycogenolysis and gluconeogenesis, which promotes hepatic glucose production 4

doi:10.1016/j.neurobiolaging.2010.06.018

Furthermore, hypothalamic inflammation alters the pulsatile secretion pattern of gonadotropin-releasing hormone (GnRH), resulting in an increase in luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratios and leading to irregular menstrual cycles and ovulatory disorders (90)

[DOI] [PubMed] [Google Scholar] 207

Jul 1 2025;83(7):e1533-e1543
