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Many antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase, utilize NADPH as a co-factor and, consequently, are dependent upon the cellular NADPH pools for activity [49]

Specificity of biogenic selenium nanoparticles for prostate cancer therapy with reduced risk of toxicity: an in vitro and in vivo study

[7] Drugs or toxins that have a pharmacological (type A) hepatotoxicity are those that have predictable dose-response curves (higher concentrations cause more liver damage) and well characterized mechanisms of toxicity, such as directly damaging liver tissue or blocking a metabolic process

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10.1074/jbc.RA119.008766

In a rat model with alternating mania- and depression-like behaviors, viral D1 overexpression in glutamatergic neurons in the medial PFC (mPFC) resulted in mania-like behavior, and termination of viral D1 overexpression alone was sufficient to induce depression-like behavior (Sonntag et al., 2014