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Sadeghian et al., 2016) and SLE, pointing at metabolic dysregulation as a shared pathogenic mechanism

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In M1-like TAMs, inducible nitric oxide synthase (iNOS)-mediated arginine metabolism produces a large amount of nitric oxide (NO), which is a effector molecule that not only has direct anti-tumor effects, but also enhances M1-like polarization through autocrine and paracrine signals (102, 106, 107).By contrast, M2-like TAMs demonstrate pronounced ARG1 upregulation, channeling arginine flux into ornithine and polyamine production

[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Finkel T

Malondialdehyde (MDA) content, superoxide dismutase (SOD) activity, and glutathione (GSH) analysis of lung tissue homogenates MDA, SOD, and GSH levels were measured MDA assay kits (Cat# A003-1-2, Nanjing Jiancheng Bioengineering Institute, Nanjing, China), SOD assay kits (Cat# A001-3-2, Nanjing Jiancheng Bioengineering Institute, Nanjing, China) and GSH assay kits (Cat# A006-2-1, Nanjing Jiancheng Bioengineering Institute, Nanjing, China) respectively in lung tissues 22

In the striatum and hippocampal regions, donepezil displayed strong selectivity for G1 AChE, although this selectivity was not observed in the cortex