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Apart from stimulating immune responses via death-associated antigens, immunogenic cell death is accompanied by the release of diverse damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), high mobility group protein 1 (HMGB1), adenosine triphosphate (ATP), heat shock proteins (HSPs), and others

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Many low-molecular-weight antioxidants have shown therapeutic potential in preclinical trials

There were more side effects, mostly gastrointestinal, in the metformin group

The resulting hybrids demonstrated exceptional adaptability to the tropical climate, rapidly spreading throughout the Americas, excluding Canada ( The success of Africanized bees in the Americas is attributed to ecological and genetic advantages over native pollinators, including higher reproductive rates, shorter development cycles, increased drone production, swarming frequency, enhanced disease resistance, and less selective nesting site choice ( In Brazil, between 2013 and 2023, there were 206.746 reported cases of bee stings, with a notable increase in the year 2023, where 33,317 cases were reported, exceeding the number of snake cases (32,420 cases) leading to 649 direct fatalities and an additional 50 deaths indirectly attributed to bee stings ( Figure 1A )

205 In conditions of adequate methionine availability, conversion of homocysteine to methionine is suppressed, and an alternate metabolic pathway is engaged to regulate homocysteine levels