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Metabolites were identified based on exact mass within 5 parts per million (ppm) and further validated by concordance with retention times of external standards

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Ann Transl Med.2018;6(24):471

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The skin is composed of two layers: the epidermal outer layer is highly cellular and provides the barrier function, and the inner dermal layer ensures strength and elasticity and gives nutritional support to the epidermis

Standard / Gradual Approach A representative reference vial is compounded at roughly methionine 25 mg/mL + inositol 50 mg/mL + choline 50 mg/mL (125 mg/mL combined MIC) with ~1000 mcg/mL B12 , though ratios such as 25/25/25 are equally common [1]