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2005;101 doi: 10.1159/000087411

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Vitamin C is not essential for carnitine biosynthesis in vivo: Verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice

AHRQ Comparative Effectiveness Reviews

Despite a series of positive findings on the beneficial therapeutic target for various cardiovascular diseases derived from the evidence from clinical trials, there is still an urgent need for more meaningful, well-designed, randomized controlled trials to better define cardiovascular pharmacotherapy, the safe window of L-carnitine, and the longer-term side effects, including potential atherosclerotic effects