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Numerous pathways for the formation of N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) have been identified in vitro and in vivo, and increased levels of melatonin metabolites, AFMK, and N-acetyl-5-methoxykynuramine (AMK) positively regulate antioxidant enzymes and negatively regulate pro-oxidative and pro-inflammatory enzymes [22]

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