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Description
Skin is the bodys largest organ and just like any other, it thrives on water
So, there is no risk of overdose
Moreover, research by Rapoport et al
Yes, for most people, long-term use at recommended doses is safe

Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of (14)C-H3B-6527 in a dog mass balance study

Myasoedov, Natalia G