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These mechanical signals operate via organized actin cytoskeletal networks and mechanosensitive transcription factors, particularly the (Yes-associated protein/Transcriptional coactivator with PDZ-binding motif (YAP/TAZ) complex (329)

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Research conducted both in vitro and in vivo has validated the safety of fucoidan, irrespective of the source of the algae (Hwang et al., 2016)

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