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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Guarnieri L, Bosco F, Ruga S, Tallarico M, Leo A, De Sarro G, Citraro R

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Because the LFCN is purely sensory, patients experience only altered sensationno muscle weakness

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Given that many extracellular factors regulate microglia and macrophage enrichment and reactivity during all disease stages, many mechanisms may define their contribution to neurodegeneration in progressive MS including the release of neurotoxic factors that may result in accumulation of mitochondrial injury and sustained pro-inflammatory cytokine production