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Tumorigenicity is believed to be the most severe challenge among the many uncertain factors of MSCs

A phase I study to evaluate two doses of whartons jelly-derived mesenchymal stromal cells for the treatment of de novo high-risk or steroid-refractory acute graft versus host disease

Additionally, evidence suggests that metal deficiency destabilizes the SOD1 protein and structural distortion of apo-SOD1 results in its aberrant oligomerization (Strange et al., 2007

Potent Antioxidant ProtectionRich in polyphenols, catechins, and EGCG, green tea extract helps combat oxidative stress and supports immune health

Its main limitation is the lack of human clinical data specifically for bone healing

SARS-CoV-2 infection generates massive ROS production and the excessive oxidative damage is responsible for cytokine storm, undermined immunity, tissue damage and severe lung disease causing ARDS and death (Silvagno et al., 2020)