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Therefore, inhibition of NF-B and downstream effector molecules is a possible underlying mechanism of the antitumor and anti-angiogenic activity of TQ in osteosarcoma[57]

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By affecting all these cellular functions already impaired in aging individuals it could explain why older, comorbid patients have the most severe outcomes with COVID-19 (312) and stimulate the use of GSH and Nrf2 enhancers as well as develop new therapies to protect mitochondria

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