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Synthesis of carnitine occurs in the kidney, liver and brain, and it is transported to other tissues in the circulation before it is taken up by tissues by carnitine transporters at the plasma membrane that are tissue-specific

In PTC and anaplastic thyroid carcinoma, somatic KEAP1 and NFE2L2 mutations activating the Nrf2 pathway were discovered (128, 129)

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[DOI] [PubMed] [Google Scholar] 67.Organ C.L., Li Z., SharpIII T.E., Polhemus D.J., Gupta N., Goodchild T.T., Tang W.H.W., Hazen S.L., Lefer D.J