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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

Development and biological characterization of a novel selective TrkA agonist with neuroprotective properties against amyloid toxicity

Oxidative stress induced inflammation initiates functional decline of tear production

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GHRP-6 also stimulates appetite pathway signaling through the same ghrelin receptor
