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The drugs implicated are numerous, including antimalarials (e.g., primaquine and chloroquine), sulfonamides, nitrofurantoins, and others

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In active demethylation, 5mC is converted into oxidized intermediates such as 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxycytosine (5caC), which can alter gene expression and cell function [337]

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It is our intent to explore this mechanism in Lyme borreliosis patients further by expanding on our preliminary data and assessing additional markers for oxidative stress, intracellular communication, and the inflammatory pathways