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Impurities or incorrect amino acid sequences can cause unpredictable effects, invalidate data, and introduce unnecessary risks, making the results of the study unreliable

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The increase in PDH phosphorylation under 5% O 2 was accompanied by a significant reduction in mitochondrial membrane potential (Supplementary Figure S6)

Thus, although SAMe shows potential as an anticancer therapy for liver tumors, key aspects must be addressed before its application in clinical practice

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We further used Esm1-CreERT2 transgenic mice in the Rosa26-mTmG Cre reporter background 30,31 to detect Esm1 + cells and their progeny