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120 In fact, the effect of -tocopherol seems to be dependent on tissue saturation with vitamin C, and both vitamins may function synergistically to provide optimal conditions for endothelial NO formation

Although CCT expression is enhanced by diverse transcription factors such as E2F (72) that is regulated by IGF1 stimulation (60), we do not discard other possible mechanisms triggered by IGF1R nuclear localization to justify the higher expression of CCT detected in U87WT cells

Overall, ferroptosis acts as a triggering factor of inflammation, affecting the bodys immune regulatory system, promoting iron ion-induced lipid peroxidation, and inducing osteoclast differentiation while inhibiting osteoblast proliferation, leading to cartilage destruction and bone erosion

AlJammaz, I

(110) Sutherland, E

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