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Also, Cabra et al

For example, individuals in the lowest quartiles for serum folate and vitamin B 12 have significantly higher concentrations of homocysteine, and men in the lowest quartile of serum pyridoxal 5-phosphate (P5P

In clinical application, sirolimus, an outstanding representative of mTOR inhibitors, is widely used to prevent rejection after solid organ transplantation and protect the safety of transplanted organs through its powerful immunosuppressive effect

Yanqin Huang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.1038/s41380-021-01331-7

Disrupting NOTCH slows diffuse intrinsic pontine glioma growth, enhances radiation sensitivity, and shows combinatorial efficacy with bromodomain inhibition