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The incidence of fatigue, cognitive impairment, insomnia, joint pain and numbness in chronic LD is increased in some studies, while others report no difference from controls

As the active methyl donor form of B12, it participates directly in the neurotransmitter synthesis pathways that matter most for mood regulation

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Online communities promoting these compounds together lack medical or scientific oversight, and anecdotal reports should not be treated as evidence of safety or efficacy
