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Figure 1 SCOPA is very prominent in Traditional Chinese Medicine (TCM), particularly for its hepatoprotective and choleretic effects

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When FSH binds to its receptor in the granulosa cells, the intracellular portion of the receptor develops a higher affinity for G proteins and APPL1, a leucine-zipper-containing protein that activates phosphatidyl-inositol-3-kinase (PI3K) and Akt, leading to transcriptional regulation and PIP3 production (Figure 3A)

This includes elevated inflammatory markers such as C-Reactive Protein (CR), Sed Rate (ESR), Procalcitonin, D-dimer, Ferritin, Neutrophils, Fibrinogen, LDH, and/or IL-6

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Additionally, complex mixtures or modified synthetic versions of these compounds are widely studied for their synergistic effects with antibiotics 58,59,60,61