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The basic metabolic parameters (metabolic activity, cell cycle analysis, LDH release, caspase-3 activity) and the protein expression of sequestosome 1 (SQSTM/p62), proliferating cell nuclear antigen (PCNA), proto-oncogene tyrosine-kinase (c-SRC), superoxide dismutase-1 (SOD1), AhR, Beclin1, and extracellular signal-regulated kinas-1/2 (ERK1/2) were measured

In the obesity group, there was a significant and clinically meaningful reduction in body weight of 4.74% at week 8, with weight continuously decreasing during the 8-week treatment period

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Jafari F, Arasteh O, Hosseinjani H, Allahyari A, Ataei Azimi S, Askari VR (2023) A critical review of methotrexate clinical interactions: role of transporters