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A systematic review (PMID: 40756949) examined its emerging use in orthopaedic sports medicine, while a 2025 pilot study (PMID: 40131143) provided early human safety data

Enzyme Activation Lysyl oxidase, the enzyme responsible for cross-linking collagen and elastin fibers (essential for tissue strength, elasticity, and proper matrix organization), absolutely requires copper as a cofactor - GHK-Cu enhances lysyl oxidase activity by ensuring adequate copper availability, thereby promoting proper collagen and elastin maturation and tissue structural integrity

Similarly, through the inhibition development of hyperhomocysteinemia, folic acid mitigates palmitate-induced inflammation and NF-B activation in HepG2 cells (Bagherieh et al