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Microglia with depleted GSH have an exacerbated ROS/RNS production, elevated pro-inflammatory cytokine release, impaired phagocytic clearance, and increased neurotoxic output (Lee et al., 2010)

The magic trio is vitamin B6 (20mg), B12 (500g as methylcobalamin), and methylfolate (400g)

Oncofetal gene SALL4 in aggressive hepatocellular carcinoma
Horn M, Nussbaumerov M, anda M, Kovov Z, Srba J, Franta Z, et al

In mouse xenograft models, this combination therapy significantly inhibited tumor growth compared to monotherapy, accompanied by increased DLAT lipoylation in tumor tissues

Cell Longev 2018, 6581970
