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Participants who reported not smoking SPECTRUMs, not wanting to continue in the study, or who were lost to follow-up from V1 to V3 did not remain eligible to participate and were withdrawn from the study

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E-cigarette liquids and aerosols contain numerous harmful chemical substances and potential carcinogens such as tobacco-specific nitrosamines, metals (nickel, tin, lead), volatile organic compounds, reactive carbonyls (acetaldehyde, formaldehyde), propylene glycol, glycerol, polycyclic aromatic hydrocarbons, in addition to nicotine and flavoring additives (3739)