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doi: 10.1016/j.ymgme.2015.09.004

G.NeteaM

Also, bearing in mind the important pathogenic role of NETosis, NK/NKT cells, and Th1/Th17 lymphocytes in the pathogenesis of THO-dependent eye inflammation [49,52], future experimental and clinical studies should investigate whether a combined administration of hypo-osmotic eye drops with immunosuppressive and anti-inflammatory drugs would have beneficial effects in the DED treatment

Italian Medicines Agency

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Target ~30 kCal/kg/day to suppress catabolism