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High-throughput screening in MADD cell lines has identified several lumichrome derivatives that restore mutant ETFDH activity at micromolar concentrations, validating the concept of pharmacological riboflavin agonists (76)

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Safety data in humans is limited, and therapy should only be considered under licensed medical supervision though research is still ongoing

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These therapies reduce NP doses, helping to avoid toxic levels of nanomaterials in animal feed