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These include: a) Aldh1a1, Aldh2, Aldh1b1, Cat, Cyp2e1, Adh3a1 and Gclm single knockouts (KO) b) Aldh1a1 and Aldh3a1 knock-in lines (both have mutated the Cys-302 of the active site) c) Aldh1a1/Aldh1b1, Aldh1b1/Aldh2, Cat/Cyp2e1 and Gclm/Nrf2 double knockouts (DKO) d) Conditional Gclc floxed strain e) Hepatocyte-specific Gclc knockout Funded by NIAAA (R24AA022057) Contact Please send inquiries and requests to: Dr

Using the GSG (glutamate-serine-glycine) index, calculated as the ratio between the plasma level of glutamate and that of serine + glycine, this study found that the GSG index was correlated with an increased level of liver enzymes, particularly gamma-glutamyltransferase, and liver fibrosis

Platinum (IV) Prodrug-1 triggers endoplasmic reticulum stress and immunogenic cell death via excessive accumulation of intracellular ROS

Judd LM, Gleeson PA, Toh BH, van Driel IR

Angew Chem Int Ed Engl.51(22):5308-32

Additional studies in multiple dystrophic mouse models have confirmed IGF-1 analog benefits in improving muscle function and reducing pathological features
