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Plant Cell 10 , 10551068 (1998)

doi: 10.1016/j.jtherbio.2016.08.003 158 JohnsonJ

Considering the interconnected molecular pathways that associate vascular and muscular health, strategically targeting the musclevasculature axis through a combined regimen of CIT and leucine supplementation alongside exercise may present a synergistic strategy for the preservation of muscle metabolism, enhancement of vascular function, and prevention of sarcopenia in the context of aging

this dominant murine substitution thus provides a relevant model of progressive -cell failure

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