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Exercise Performance : Glutathione neutralizes free radicals formed during exercise, improves exercise performance and reduces muscle fatigue

241 A phase 1/2 (ECHO-202/KEYNOTE-037) trial evaluating the effectiveness of the IDO1 inhibitor epacadostat combined with pembrolizumab on advanced solid tumors showed a high objective response rate (ORR) of 40.3% overall and 61.9% in malignant melanoma patients, demonstrating promising antitumor efficacy

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Nature 453 , 553556 (2008)

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This activation initiated a signaling cascade that increased the production of type I interferons and proinflammatory cytokines, promoting T cell priming and enhancing infiltration of natural killer and dendritic cells