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The present systematic review and meta-analysis included four limitations: (1) there was substantial heterogeneity among the studies included in the meta-analysis

For example, it reacts with nitric oxide with a formation of peroxynitrite (ONOO-), a strong oxidant, which leads to formation of reactive intermediates due to spontaneous decomposition [9-10]

In the blood, oxidized Fe 3+ binds to transferrin and can be transported in this state until it reaches its target cell and binds to transferrin receptor-1 on the cell's surface (133)

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In addition, more in vivo studies using treatment with L-carnitine after injury are needed since several studies used pretreatment and/or in vitro models