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[54] Ligand binding [edit] GPCRs include one or more receptors for the following ligands: sensory signal mediators (e.g., light and olfactory stimulatory molecules)

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The conditions most commonly associated with unexplained hypercobalaminemia include: Liver disease

"Thermoregulatory control during pregnancy and lactation in rats." Journal of Applied Physiology 83.3 (1997): 837-844

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If you dont have enough B12, you can end up developing a certain kind of anemia known as megaloblastic anemia
