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Using different selective VMAT2 inhibitors was unanimously considered the first-line pharmacological option when an antidyskinetic strategy is necessary, and improvement of at least 30% relative to the baseline Abnormal Involuntary Movements Scale total score was considered clinically significant, representing in another study a two-point decrease in score for a minimal clinically important difference attributed to an intervention

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Secretion rate of each analyte for each sample was calculated as the raw concentration (unit/mL) multiplied by the flow rate (mL/min)

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n = 3 independent mice