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Two doses of edaravone were selected to evaluate if the anti-oxidant exert a dose-dependent effect

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A recent MitoQ clinical study found that chronic administration of MitoQ in healthy middle aged to older adults improved brachial artery flow-mediated dilation by 42% in just 6 weeks and significantly reduced aortic stiffness (measured by carotid-femoral pulse wave velocity) and plasma-oxidized LDL levels (a marker of oxidative stress)

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With respect to desensitization, all those data support the idea that agonists are able to promote a different regulation of OR as demonstrated for other GPCR such as the histamine H2 receptors (Alonso et al., 2014)