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In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig

Toxicity study CD-1 mice A 26-week Good Laboratory Practice (GLP) toxicology study was conducted at Inotiv according to the protocol, Inotivs Standard Operating Procedures and in compliance with the current US Food and Drug Administration GLP Regulations for Non-Clinical Studies (21 CFR Part 58)

Am J Physiol Gastrointest Liver Physiol 289:G367G375 Booth C, Evans GS, Potten CS (1995) Growth factor regulation of proliferation in primary cultures of small intestinal epithelium

CD19 + CD24 hi CD38 hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients