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These agents directly stimulate salivary flow by agonizing the M3 muscarinic receptors located on salivary acinar cells

Iron accumulation in the mitochondria causes a lack of Fe-S clusters, which leads to increased ROS levels in the mitochondria [82], followed by ferroptosis due to lipid peroxide accumulation [83]

10.1073/pnas.220426197 Proc

They enable controlled release, site-specific targeting, enhanced therapeutic outcomes, and a reduced dosing frequency (101)

doi: 10.1085/jgp.200609552

Aranda A, Querol A, del Olmo M (2002) Correlation between acetaldehyde and ethanol resistance and expression of HSP genes in yeast strains isolated during the biological aging of sherry wines