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Finally, for the complex entity of nociplastic pain, defined by CNS sensitization in the absence of clear neural or tissue damage, we review the characteristic clinical phenotype, supportive questionnaires such as Central Sensitization Inventory (CSI), and the challenges in identifying objective biomarkers

doi: 10.1371/journal.pone.0170806 116 NaingAPapadopoulosKPPishvaianMJRahmaOHannaGJGarraldaEet al

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Gerlovina, I., Gerlovin, B., Rodrguez-Barraquer, I., & Greenhouse, B