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This present study not only revealed the expression changes of vasoactive intestinal peptide [and its] receptors within human nucleus pulposus tissue, but also demonstrated [its] protective effects [against] degeneration, said Jingchuan Sun, professor in the Department of Orthopedic Surgery in Changzheng Hospital, and co-lead author of the study

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Daily doses of 100 mg increased NAD+ by about 10%, 300 mg by 48%, and 1000 mg by 139% [16]

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