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[Google Scholar] Johansson C, Castoldi AF, Onishchenko N, Manzo L, Vahter M, Ceccatelli S

10.1016/j.mad.2006.02.007 39 del RioM

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In medicine, when a prescribed substance is believed to have caused an adverse effect (such as weight gain), its reported - meaning its publicly registered so physicians and scientists can learn about it and be on the lookout for similar problems

These sex-specific reductions in venous function, if they also proved to occur in human veins, may explain the greater incidence of varicose veins in females [59]

One of the most consistent findings is a reduction in circulating free T3 (fT3) levels, often without a corresponding rise in TSH, suggesting a non-pathological downregulation of thyroid activity [10,12]