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"Novel recombinant fusion protein analogues of insulin-like growth factor (IGF)-I indicate the importance of the N-terminus and C-terminus for IGF-receptor binding." Journal of Molecular Endocrinology

Maneli MH, Wiesner L, Tinguely C, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] Freeman B

HBM captures the impact of all exposure sources and includes the influence of toxicokinetics and bioaccessibility

Furthermore, after MPTP administration, dopamine and its metabolite levels were measured in mice, revealing lower concentrations of these compounds in animals deprived of the protective effect of -HB [56]

Alignments were then manually optimized with the rationale to avoid insertion/deletion within trans-membrane fragments, but rather move them into loops, and to anchor the beginning or the end of TM helices on special residues, common to the two proteins, like for instance, positively charged residues inside, proline to introduce kinks in helices, etc