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Thus, although transport limits L-carnitine production, it is not the main factor controlling the biotransformation in laboratory strains [26]

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The blood lipids (e.g., free fatty acid and triglyceride) and cytokines (e.g., leptin) in mice with global AR knockout (ARKO) or tissue-specific knockout (e.g., liver and skeletal muscle) are significantly increased, and they are prone to suffer from obesity, insulin resistance (IR), and liver fibrosis ( As the metabolic center of energy substrates, mitochondria produce a large amount of adenosine triphosphate (ATP) to meet the energy needs of cells

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The role of carnitine in intracellular metabolism