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The upregulation of G6PD, AKR1B1, ITGAV, and TGF1 in OVCAR5 CBPR cells was also identified in the tumors of platinum-resistant compared to platinum-sensitive high grade serous ovarian cancer (HGSOC) patients
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The initial cases of glutathione reductase deficiency were attributed to genetic factors, and subsequent studies have pinpointed the specific DNA variations associated with the deficiency
