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A potent endogenous antioxidant, glutathione is essential for the liver's phase I and phase II detoxification.* However, negative lifestyle issues and adverse conditions that affect liver health can result in a decreased amount of glutathione in the liver

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Laron Z., Pertzelan A., Mannheimer S

Intrathecal HIV-1 envelope glycoprotein Gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines

It exhibits anti-infective, anti-inflammatory, and antineoplastic activities (Rossignol, 2014

Low Vitamin D levels may also weaken the blood-brain barrier, making it easier for rogue immune cells to enter the central nervous system

In conclusion, glutamine antimetabolites effectively inhibit tumor growth while improving the anti-tumor immune response through multiple mechanisms, revealing the close interaction between glutamine metabolism and immune response in the TME (Fig