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Neuroprotective Effects of an Aqueous Extract of Forsythia viridissima and Its Major Constituents on Oxaliplatin-Induced Peripheral Neuropathy

This reduces the leaf internal CO 2 , which leads to the formation of ROS such as hydroxyl radicals (OH) singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), alkoxyl radical (RO) and superoxide radical (O 2 ) mainly by enhancing electrons leakage to oxygen molecule 1,2,3,4

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At 25M of menadione, there was a 13.3-fold increase for HEK-293 cells and 11.5-fold increase for K-562 cells in the amount of oxidized glutathione compared to the control

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10.1002/1531-8249(199905)45:5 3.0.co;2-z 228 ShobanaC.Ramesh KumarR.SumathiT