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MEG3 exerts its inhibitory effect on the PI3K/Akt signaling pathway through various mechanisms, and the reduction in PI3K/Akt pathway activity leads to decreased signals for neuronal overgrowth and survival, subsequently mitigating oxidative stress and inflammation, and protecting neurons ( 5.3 circRNAs and methamphetamine addiction Circular RNAs (circRNAs) form a closed-loop structure with covalent bonds, lacking a polyadenylation tail at the 3end and a cap structure at the 5end (Memczak et al., 2013

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Cellular stress, often observed in the autistic brain [158], activates p53, which inhibits the activity of mTORC1 via AMPK and TSC2 activation [303]

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