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doi:10.1007/s11154-022-09748-3 Gregori G, Celli A, Barnouin Y, et al

Also, IL-10 is one of the cytokines involved in the immunosuppressive process

7, 271275 10.1038/sj.embor.7400645 [DOI] [PMC free article] [PubMed] [Google Scholar] 80.Gallogly M.M., Starke D.W., Leonberg A.K., Ospina S.M

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Results Establishment of CRC Drug-Tolerant Persister Cell Models While modeling the response to the chemotherapeutic drug 5-FU in the CRC cell line HCT116, which has exquisite sensitivity, we observed that the vast majority of the cells were killed within 9 days of exposure to the drug at a concentration 10-fold higher than the IC 50 value ( Figure 1A )

Collectively, these findings underscore that kratoms complex pharmacology arises from the combined actions of alkaloids with divergent receptor selectivities, efficacies, and signaling biases rather than from a single dominant mechanism