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Under a high-iron diet, ferritin-deficient mice demonstrated severe heart damage and hypertrophic cardiomyopathy with a distinctive iron death molecular signature, while SLC7A11 overexpression in these mice forestalled cardiac iron death and remodeling [563]

doi: 10.1002/eji.1830261229

Lactate, through HIF-1, promotes M2 polarization of TAMs, upregulates vascular endothelial growth factor (VEGF) and arginase-1(ARG-1) expression

Five subjects reported five AEs that were assessed as possibly related to the investigational drug, resulting in an adverse reaction incidence rate of 41.7% (5/12)

Refrigerate at 28 C immediately

"Interphalangeal joint anatomy"